Reduced Naþ and higher Kþ channel expression and function contribute to right ventricular origin of arrhythmias in Scn5aþ/2 mice
نویسندگان
چکیده
Claire A. Martin1, Urszula Siedlecka2, Kristin Kemmerich3, Jason Lawrence4, James Cartledge2, Laila Guzadhur5, Nicola Brice4, Andrew A. Grace5, Christof Schwiening1, Cesare M. Terracciano2 and Christopher L.-H. Huang1,5 Physiological Laboratory, University of Cambridge, Downing Site, Cambridge CB2 3EG, UK Laboratory of Cell Electrophysiology, Heart Science Centre, National Heart and Lung Institute, Imperial College London, Harefield Hospital, Harefield, Middlesex UB9 6JH, UK Laboratory of Molecular Biology, Medical Research Council, Hills Road, Cambridge CB2 0QH, UK Takeda Cambridge Limited, Cambridge Science Park, Cambridge CB4 0PA, UK Department of Biochemistry, University of Cambridge, Downing Site, Cambridge CB2 1QW, UK
منابع مشابه
Mechanisms, manifestations, and management of digoxin toxicity
Well known functional structures are implicated in the development of digoxin toxicity in the heart: (Naþ/Kþ-) Mg2þ-ATPase, the Naþ–Ca2þ exchanger, and sarcoplasmic reticulum; there is both direct and indirect involvement of sodium, potassium, and calcium ions. The therapeutic effect of digoxin in doses between 1 and 2 ng/ml involves the alpha 2 isoform of Naþ/Kþ-ATPase. Toxic effects occur at ...
متن کاملRight ventricular Hemodynamic Alteration after Pulmonary Valve Replacement in Children with Congenital Heart Disease
Introduction: In patients who underwent surgery to repair Tetralogy of Fallot, right ventricular dilation from pulmonary regurgitation may be result in right ventricular failure, arrhythmias and cardiac arrest. Hence, pulmonary valve replacement may be necessary to reduce right ventricular volume overload. The aim of present study was to assess the effects of pulmonary valve replacement on rig...
متن کاملReduced Na+ and higher K+ channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice
Brugada syndrome (BrS) is associated with ventricular tachycardia originating particularly in the right ventricle (RV). We explore electrophysiological features predisposing to such arrhythmic tendency and their possible RV localization in a heterozygotic Scn5a+/- murine model. Na(v)1.5 mRNA and protein expression were lower in Scn5a+/- than wild-type (WT), with a further reduction in the RV co...
متن کاملArrhythmias in Patients With Pulmonary Hypertension; A Narrative Review of the Current Literature
Incidence and prognostic relevance of supraventricular arrhythmias were evaluated in nine studies. These studies investigated patients with different forms of pulmonary hypertension. Supraventricular arrhythmias were more often found in patients with group two pulmonary hypertension. Common findings in these patients were elevated right atrial pressure and diameters and reduced tricuspid annula...
متن کاملReduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract.
RATIONALE In patients with Brugada syndrome, arrhythmias typically originate in the right ventricular outflow tract (RVOT). The RVOT develops from the slowly conducting embryonic outflow tract. OBJECTIVE We hypothesize that this embryonic phenotype is maintained in the fetal and adult RVOT and leads to conduction slowing, especially after sodium current reduction. METHODS AND RESULTS We det...
متن کامل